Mode of reactions between xanthine oxidase and aromatic nitro compounds.
نویسندگان
چکیده
منابع مشابه
QSAR and SAR Studies on the Reduction of Some Aromatic Nitro Compounds by Xanthine Oxidase
This work describes QSAR and SAR studies on the reduction of 27 aromatic nitro compounds by xanthine oxidase using both distance-based topological indices and quantum molecular descriptors along with indicator parameters. The application of a multiple linear regression analysis indicated that a combination of distance-based topological indices with the ad hoc molecular descriptors and the indic...
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In nucleophilic aromatic photosubstitution, just as in aromatic substitution in the ground state, substituents can have directing and activating effects. Four rules, which describe orientation of nucleophilic substitution in the excited state, can now be formulated. They are: (a) meta-activation by the nitro group (b) ortho/para-activation by the methoxy group (and probably also by other electr...
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A reaction from various kinds of nitroquinoline with hydroxylamine in potassium hydroxide alkalinity produced a novel product, furazanoquinoline, besides the known amino derivatives. The products obtained were furazano [3,4-f] quinoline (5) from 5-nitroquinoline (1) and 6-nitroquinoline (6), and furazano [3,4-h] quinoline (10) from 7-nitroquinoline (8) and 8-nitroquinoline (11). The reaction me...
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Investigations of the inhibition of the activity of xanthine oxidase in vitro have yielded a number of substances which have been reported to exert marked inhibitory actions at low concentrations. Among these are p-aminophenol in its oxidized form (l), pyrogallol (a), bromoacetophenone (3)) 6-pteridylaldehyde (4)) and 6-hydroxymethylpterin (5). An examination of the structures of these compound...
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An efficient one-pot reductive acetylation of aromatic nitro compounds is developed without isolating the intermediate amine. The nitro compound is efficiently reduced by sodium borohydride and catalytic amount of Pd-C in MeOH-water media in presence / absence of alkali, and the amine thus generated is acetylated by acetic anhydride in situ in excellent yields through easy work-up. The techniqu...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1981
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.4.101